Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer

Lipocalin 2 is a siderophore-binding protein that regulates iron homeostasis. expression elevated in multiple tumor types; however, the mechanisms drive progression upon remain unclear. When over-expressed, it leads to resistance 5-fluorouracil colon cancer cell lines vitro and vivo by inhibiting ferroptosis. inhibits ferroptosis decreasing intracellular levels stimulating of glutathione peroxidase4 component cysteine glutamate antiporter, xCT. The increase xCT dependent on increased ETS1 over-expressing cells. Inhibiting function with monoclonal antibody decrease chemo-resistance transformation vitro, xenograft mouse models. exhibit positive correlation human samples suggesting pathway we have identified operative samples. These results indicate potential therapeutic target described our study can serve as basis for patients who do not respond chemotherapy.